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acetaminophen effects on glutathione PharmGKB summary: Pathways of metabolism at the therapeutic versus toxic doses luxe
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The π and μ classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein: protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)
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Lower GSH levels do not necessarily have to be related to increased oxidative stress, but rather to suppressed cysteine pools as a result of a specific diet
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