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Steroidal 5α-Reductase: A Therapeutic Target for Prostate Disorders | IntechOpen

TB-500 is a considerably larger, highly charged polypeptide dominated by lysine, glutamate and aspartate residues, with an N-terminal acetyl cap and a single methionine that is often monitored as an oxidation-prone site during stability and forced-degradation studies

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Activation of sirtuins, particularly the NAD‐dependent deacetylase SIRT1, enhances mitochondrial resilience by deacetylating and activating PGC‐1α, which in turn upregulates key antioxidant enzymes like catalase, glutathione peroxidase, and manganese superoxide dismutase [258, 259]