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The only heteroatom present in the sample base on the molecular formula given is an oxygen atom
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Notably, both hyperandrogenemia and chronic low-grade inflammation can modulate DNA methyltransferase (DNMT) activity, leading to aberrant methylation of the AMH promoter in granulosa cells and subsequent impairment of folliculogenesis in PCOS ( Concerning histone modifications, granulosa cells from PCOS patients exhibit enhanced histone deacetylase (HDAC) activity, which decreases acetylation levels of pro-inflammatory cytokines ( e.g ., TNF-α, IL-6) and suppresses their transcriptional activation
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