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Upon oxidative insults, a kinase cascade consisting of NSY-1/ASK mitogen-activated protein kinase kinase kinase (MAPKKK) is phosphorylated to phosphorylate SEK-1/MAPKK, which phosphorylates PMK-1/p38 MAPK, which then phosphorylates SKN-1 to allow SKN-1’s nuclear translocation and transcription of antioxidant genes (Figure 3, [68])