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Using distinct HIF-1α antibodies for staining macrophages, dual-positive immunofluorescence for HIF-1α + and CD206 + macrophages was detected in proximity to capillaries (186), indicating that vascular neogenesis in jDM patients is regulated by the VEGF/HIF pathway, inducing HIF-1α and promoting CD206 expression in macrophages, which may lead to hypoxic damage to capillaries in DM patients
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