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In a combination of cognition and neural cell transplantation approaches, they have recently demonstrated that neural cell transplantation in the hippocampus of the genetically manipulated mouse model of Alzheimer’s disease (AD), [PDGF promoter-driven amyloid precursor protein (PDAPP) transgenic (Tg) mice], improved both spatial learning deficits and neuropsychiatric symptoms such exhibited in the AD, including motivation, anxiety-like behavior, and depression [152]