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Whilst both markers showed an increase in Creutzfeldt-Jakob disease (CJD) cases, a disease associated with severe astrogliosis, in controls, C3 displayed high non-specific background staining in human tissue, whereas and GBP2 was highly abundant in GFAP+ astrocytes in disease tissue and was completely absent in control tissue (Hartmann et al., 2019)
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Leads to impaired homocysteine remethylation and increased homocysteine levels
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