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Cdc42 and MT1-MMP, increased by the downstream effects of intracellular pathogens on human host cells (see above steps), are critical for invasion of many cancer types [27] but also cdc42 may be linked with formation of tunnelling nanotubes which may enable further cell to cell spread of invasive intracellular bacteria (Fig

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Glutamate/Glutamine Central to the concept of metabolic reprogramming is glutamine bioavailability, as some cancer cells have been shown to depend heavily on this amino acid for rapid proliferation and protection against ROS (Daye and Wellen, 2012