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In HNSCC, the acquisition of stem-like characteristics has been strongly correlated with the upregulation of markers such as SOX2, Bmi-1, CD44, Nanog, and aldehyde dehydrogenase
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Recent reviews of injectable peptide therapy in adults make the same point repeatedly, which is that these agents are widely used in wellness settings with a thinner evidence base than their marketing implies (an International Journal of Molecular Sciences review of therapeutic peptides in aesthetic, metabolic, and endocrine conditions, covering reported effects, safety considerations, and clinical application)
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