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At the intestinal level, ethanol induces villous atrophy, reduces the expression of tight junction proteins (ZO-1, occludin), and increases paracellular permeability, thereby facilitating microbial translocation and exacerbating intestinal inflammation [99]
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Cigarette smoke-induced SSG accumulation in lung proteins promotes alveolar epithelial apoptosis, while GRX1 overexpression rescues cell survival and reduces airway inflammation (86)
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