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Excessive iron loading increases the expression of M1-associated inflammatory mediators, including IL-6, TNF-α, and IL-1β, while suppressing M2 markers such as transglutaminase 2 (TGM2), so efficiently guiding polarization toward the pro-inflammatory M1 phenotype (97)
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The morphological and lower immunoreactivity of GPX4 is consistent with previous results that show GPX4 downregulation in MS lesion 14
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