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It has been suggested that the diversity of effects might be understood in terms of inhibition of a common regulatory mechanism such as protein phosphorylation.151 However, McDonagh has recently proposed that bilirubin may be a so-called promiscuous inhibitor, cautioning that effects observed in vitro may be nonspecific and not related to in vivo mechanism(s) of toxicity.152 “Promiscuous inhibitors” have high hydrophobicity, high molecular flexibility, and the ability to form microaggregates, properties also shared by bilirubin

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Hu J., Cao J., Topatana W., et al., “Targeting Mutant p53 for Cancer Therapy: Direct and Indirect Strategies,” Journal of Hematology & Oncology 14, no