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Treatment with semaglutide 2.4 mg also significantly improved symptoms, evaluated with the Kansas City Cardiomiopathy Questionnaire, and physical limitations, evaluated with the 6 min walking test, in the STEP-HFpEF trial, enrolling 529 patients with obesity and HF with preserved ejection fraction 89
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LPA (unspecified species) modulates immune cell function, promotes angiogenesis and fibrosis, and fosters an immunosuppressive TME that supports tumor growth (98, 99)
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