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Though more work is needed to understand how these biophysical and signaling events occur at the atomic level, they nonetheless suggest how ceramides contribute in such a substantial way to diverse cellular events and ultimately cardiometabolic pathologies

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Interestingly, type I IFN targets also human neutrophils, for instance by prolonging their survival 16 , or by inducing the expression of CXCL10 mRNA 17 and the production of biologically active TNF-related apoptosis-inducing ligand (TRAIL) 18