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MDA and 4-HNE adducts play a critical role in multiple cellular processes and can participate in secondary deleterious reactions (e.g., crosslinking) by promoting intramolecular or intermolecular protein/DNA crosslinking that may alter the functional characteristics of biomolecules, which may aggravate the pathophysiology of the disease
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Elimova E, Kim SM, Wang X, Shimodaira Y, Sohn BH, Skinner HD, Lee JH, Weston BR, Bhutani MS, Minsky B, Rice DC, Hwang JE, Swisher SG, Hofstetter WL , Blum MA, Maru D, Ajani JA, Lee JS
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