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The cytoplasmic and the mitochondrial [NAD + ]/[NADH] couples [57], which are roughly 99.9% and 87% oxidized, respectively, in healthy cells [56,58] become more reduced with aging, while the cytoplasmic and most likely also the mitochondrial [NADP + ]/[NADPH] couple, which are both roughly 99% reduced in healthy cells [56,58] become more oxidized with aging
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