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Additional research confirmed TB-500’s actin-sequestering mechanism promotes cell motility at concentrations as low as 0.1–1.0 µg/mL in cell culture models
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2008), validating the use of abatacept, which blocks the interaction between T cells and dendritic cells or B cells through CD28 on the T cells with CD86 or CD80 on B cell or the dendritic cell, i.e., co-stimulatory signal
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