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While the extracellular matrix (ECM), fibroblasts, and inflammatory mediators have been historically investigated as separate branches of biology, it has become increasingly necessary to consider them as parts of a complex and tightly regulated system that becomes dysregulated in fibrosis
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The more models and more agents employed (NOS-blockers, NOS-substrate, combination of the NO synthase-blocker and NO-synthase-substrate) ascertains for BPC 157/NO-system the more precise relationships were defined [124,125]
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