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Recent evidence shows that HSP70s are involved into transmembrane protein translocation via entropic pulling (Rukes et al., 2024), into the protection of damaged muscle fibers via calcium reuptake from the sarcoplasm to the reticulum (Barfoot et al., 2025), and into the regulation of enzymes that mark proteins with ultraviolet-dependent damage (Zeng et al., 2025)

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ReACp53, designed by Soragni et al., is a peptide that suppresses mutant p53 aggregation, restores the wild-type conformation of mutant p53, and promotes its nuclear localization to increase its transcriptional activity