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Clinically, the syndrome presents with a mélange of mostly non-specific symptoms including unrelenting fatigue persisting over more than 6 months, exertional intolerance, sleep disturbance, abnormal function in the cognitive, emotional, speech and memory domains, hypersensitivity to light and noise, psychomotor slowness and orthostatic intolerance ( On the pathobiological level, ME/CFS is no less complex

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